Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis

INTRODUCTION: Nonalcoholic steatohepatitis (NASH) is largely driven by the dysregulation of liver metabolism and inflammation. Bile acids and their receptor Farnesoid X receptor (FXR) play a critical role in the disease development. Here, we investigated whether INT-767, the newly-identified dual FX...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Hu, Ying-Bin, Liu, Xin-Yu, Zhan, Wei
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2018
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052932/
https://ncbi.nlm.nih.gov/pubmed/30038487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S170518
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