FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective roles in diabetes- and obesity-related kidney disease. Here, we determined whether these effects are mediated through differ...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Soc Nephrol
Egile Nagusiak: Wang, Xiaoxin X., Wang, Dong, Luo, Yuhuan, Myakala, Komuraiah, Dobrinskikh, Evgenia, Rosenberg, Avi Z., Levi, Jonathan, Kopp, Jeffrey B., Field, Amanda, Hill, Ashley, Lucia, Scott, Qiu, Liru, Jiang, Tao, Peng, Yingqiong, Orlicky, David, Garcia, Gabriel, Herman-Edelstein, Michal, D’Agati, Vivette, Henriksen, Kammi, Adorini, Luciano, Pruzanski, Mark, Xie, Cen, Krausz, Kristopher W., Gonzalez, Frank J., Ranjit, Suman, Dvornikov, Alexander, Gratton, Enrico, Levi, Moshe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Nephrology 2018
Gaiak:
Basic Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748904/
https://ncbi.nlm.nih.gov/pubmed/29089371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020222
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