FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective roles in diabetes- and obesity-related kidney disease. Here, we determined whether these effects are mediated through differ...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Wang, Xiaoxin X., Wang, Dong, Luo, Yuhuan, Myakala, Komuraiah, Dobrinskikh, Evgenia, Rosenberg, Avi Z., Levi, Jonathan, Kopp, Jeffrey B., Field, Amanda, Hill, Ashley, Lucia, Scott, Qiu, Liru, Jiang, Tao, Peng, Yingqiong, Orlicky, David, Garcia, Gabriel, Herman-Edelstein, Michal, D’Agati, Vivette, Henriksen, Kammi, Adorini, Luciano, Pruzanski, Mark, Xie, Cen, Krausz, Kristopher W., Gonzalez, Frank J., Ranjit, Suman, Dvornikov, Alexander, Gratton, Enrico, Levi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748904/
https://ncbi.nlm.nih.gov/pubmed/29089371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020222
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