Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

[Image: see text] Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating evidence points to their role in malignant transformations, chemotaxis, metastasis, and survival signaling and may contribute to...

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Autores principales: Albaugh, Pam, Fan, Yi, Mi, Yuan, Sun, Fangxian, Adrian, Francisco, Li, Nanxin, Jia, Yong, Sarkisova, Yelena, Kreusch, Andreas, Hood, Tami, Lu, Min, Liu, Guoxun, Huang, Shenlin, Liu, Zuosheng, Loren, Jon, Tuntland, Tove, Karanewsky, Donald S., Seidel, H. Martin, Molteni, Valentina
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2012
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025649/
https://ncbi.nlm.nih.gov/pubmed/24900443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200261d
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