Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

[Image: see text] In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and e...

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Egile Nagusiak: Dowling, James E., Chuaqui, Claudio, Pontz, Timothy W., Lyne, Paul D., Larsen, Nicholas A., Block, Michael H., Chen, Huawei, Su, Nancy, Wu, Allan, Russell, Daniel, Pollard, Hannah, Lee, John W., Peng, Bo, Thakur, Kumar, Ye, Qing, Zhang, Tao, Brassil, Patrick, Racicot, Vicki, Bao, Larry, Denz, Christopher R., Cooke, Emma
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2012
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025639/
https://ncbi.nlm.nih.gov/pubmed/24900464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200257n
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