Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo

[Image: see text] In this letter, we describe the design, synthesis, and structure–activity relationship of 5-anilinopyrazolo[1,5-a]pyrimidine inhibitors of CK2 kinase. Property-based optimization of early leads using the 7-oxetan-3-yl amino group led to a series of matched molecular pairs with lowe...

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Detalhes bibliográficos
Main Authors: Dowling, James E., Alimzhanov, Marat, Bao, Larry, Block, Michael H., Chuaqui, Claudio, Cooke, Emma L., Denz, Christopher R., Hird, Alex, Huang, Shan, Larsen, Nicholas A., Peng, Bo, Pontz, Timothy W., Rivard-Costa, Caroline, Saeh, Jamal Carlos, Thakur, Kumar, Ye, Qing, Zhang, Tao, Lyne, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027246/
https://ncbi.nlm.nih.gov/pubmed/24900749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400197u
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