Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo

[Image: see text] The Wnt pathway is an evolutionarily conserved and tightly regulated signaling network with important roles in embryonic development and adult tissue regeneration. Impaired Wnt pathway regulation, arising from mutations in Wnt signaling components, such as Axin, APC, and β-catenin,...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Dowling, James E., Alimzhanov, Marat, Bao, Larry, Chuaqui, Claudio, Denz, Christopher R., Jenkins, Emma, Larsen, Nicholas A., Lyne, Paul D., Pontz, Timothy, Ye, Qing, Holdgate, Geoff A., Snow, Lindsay, O’Connell, Nichole, Ferguson, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789659/
https://ncbi.nlm.nih.gov/pubmed/26985319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00452
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