Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

[Image: see text] In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and e...

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Main Authors: Dowling, James E., Chuaqui, Claudio, Pontz, Timothy W., Lyne, Paul D., Larsen, Nicholas A., Block, Michael H., Chen, Huawei, Su, Nancy, Wu, Allan, Russell, Daniel, Pollard, Hannah, Lee, John W., Peng, Bo, Thakur, Kumar, Ye, Qing, Zhang, Tao, Brassil, Patrick, Racicot, Vicki, Bao, Larry, Denz, Christopher R., Cooke, Emma
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2012
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025639/
https://ncbi.nlm.nih.gov/pubmed/24900464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200257n
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