Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

[Image: see text] In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and e...

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Detalhes bibliográficos
Main Authors: Dowling, James E., Chuaqui, Claudio, Pontz, Timothy W., Lyne, Paul D., Larsen, Nicholas A., Block, Michael H., Chen, Huawei, Su, Nancy, Wu, Allan, Russell, Daniel, Pollard, Hannah, Lee, John W., Peng, Bo, Thakur, Kumar, Ye, Qing, Zhang, Tao, Brassil, Patrick, Racicot, Vicki, Bao, Larry, Denz, Christopher R., Cooke, Emma
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025639/
https://ncbi.nlm.nih.gov/pubmed/24900464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200257n
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