Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

[Image: see text] In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and e...

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Auteurs principaux: Dowling, James E., Chuaqui, Claudio, Pontz, Timothy W., Lyne, Paul D., Larsen, Nicholas A., Block, Michael H., Chen, Huawei, Su, Nancy, Wu, Allan, Russell, Daniel, Pollard, Hannah, Lee, John W., Peng, Bo, Thakur, Kumar, Ye, Qing, Zhang, Tao, Brassil, Patrick, Racicot, Vicki, Bao, Larry, Denz, Christopher R., Cooke, Emma
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2012
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025639/
https://ncbi.nlm.nih.gov/pubmed/24900464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200257n
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