Structure-Based Design of Potent and Selective CK1γ Inhibitors

[Image: see text] Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe a structure-based approach that...

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Detalhes bibliográficos
Main Authors: Huang, Hongbing, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Chakka, Nagasree, O’Connor, Anne, DiMauro, Erin F., Dovey, Jennifer, Epstein, Oleg, Grubinska, Barbara, Goldstein, Jon, Gunaydin, Hakan, Hua, Zihao, Huang, Xin, Huang, Liyue, Human, Jason, Long, Alex, Newcomb, John, Patel, Vinod F., Saffran, Doug, Serafino, Randy, Schneider, Steve, Strathdee, Craig, Tang, Jin, Turci, Susan, White, Ryan, Yu, Violeta, Zhao, Huilin, Wilson, Cindy, Martin, Matthew W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025826/
https://ncbi.nlm.nih.gov/pubmed/24900428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300278f
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