Structure-Based Design of Potent and Selective CK1γ Inhibitors

[Image: see text] Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe a structure-based approach that...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Hongbing, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Chakka, Nagasree, O’Connor, Anne, DiMauro, Erin F., Dovey, Jennifer, Epstein, Oleg, Grubinska, Barbara, Goldstein, Jon, Gunaydin, Hakan, Hua, Zihao, Huang, Xin, Huang, Liyue, Human, Jason, Long, Alex, Newcomb, John, Patel, Vinod F., Saffran, Doug, Serafino, Randy, Schneider, Steve, Strathdee, Craig, Tang, Jin, Turci, Susan, White, Ryan, Yu, Violeta, Zhao, Huilin, Wilson, Cindy, Martin, Matthew W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2012
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025826/
https://ncbi.nlm.nih.gov/pubmed/24900428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300278f
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