Structure-Based Design of Potent and Selective CK1γ Inhibitors

[Image: see text] Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe a structure-based approach that...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Huang, Hongbing, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Chakka, Nagasree, O’Connor, Anne, DiMauro, Erin F., Dovey, Jennifer, Epstein, Oleg, Grubinska, Barbara, Goldstein, Jon, Gunaydin, Hakan, Hua, Zihao, Huang, Xin, Huang, Liyue, Human, Jason, Long, Alex, Newcomb, John, Patel, Vinod F., Saffran, Doug, Serafino, Randy, Schneider, Steve, Strathdee, Craig, Tang, Jin, Turci, Susan, White, Ryan, Yu, Violeta, Zhao, Huilin, Wilson, Cindy, Martin, Matthew W.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025826/
https://ncbi.nlm.nih.gov/pubmed/24900428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300278f
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars