Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal antibodies. We here show that BCMA is universally expressed on the MM cell surface and determine specific anti-MM activity of J6M...

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Detalhes bibliográficos
Main Authors: Tai, Yu-Tzu, Mayes, Patrick A., Acharya, Chirag, Zhong, Mike Y., Cea, Michele, Cagnetta, Antonia, Craigen, Jenny, Yates, John, Gliddon, Louise, Fieles, William, Hoang, Bao, Tunstead, James, Christie, Amanda L., Kung, Andrew L., Richardson, Paul, Munshi, Nikhil C., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023420/
https://ncbi.nlm.nih.gov/pubmed/24569262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-535088
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