Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma

B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human multiple myeloma (MM), has not been effectively targeted with therapeutic monoclonal antibodies. We here show that BCMA is universally expressed on the MM cell surface and determine specific anti-MM activity of J6M...

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Bibliografiske detaljer
Main Authors: Tai, Yu-Tzu, Mayes, Patrick A., Acharya, Chirag, Zhong, Mike Y., Cea, Michele, Cagnetta, Antonia, Craigen, Jenny, Yates, John, Gliddon, Louise, Fieles, William, Hoang, Bao, Tunstead, James, Christie, Amanda L., Kung, Andrew L., Richardson, Paul, Munshi, Nikhil C., Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023420/
https://ncbi.nlm.nih.gov/pubmed/24569262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-535088
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