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APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) progression in vivo. BCMA downregulation strongly decreases viability and MM colony formation; conversely, BCMA overexpressi...
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| Izdano u: | Blood |
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| Glavni autori: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4920023/ https://ncbi.nlm.nih.gov/pubmed/27127303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-691162 |
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