APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) progression in vivo. BCMA downregulation strongly decreases viability and MM colony formation; conversely, BCMA overexpressi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Tai, Yu-Tzu, Acharya, Chirag, An, Gang, Moschetta, Michele, Zhong, Mike Y., Feng, Xiaoyan, Cea, Michele, Cagnetta, Antonia, Wen, Kenneth, van Eenennaam, Hans, van Elsas, Andrea, Qiu, Lugui, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920023/
https://ncbi.nlm.nih.gov/pubmed/27127303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-691162
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