Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms remain elusive as to whether myeloma-supporting OCs also induce suppressive immune bone marrow (BM) microenvironment. Here, we f...

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Опубликовано в: :Blood
Главные авторы: An, Gang, Acharya, Chirag, Feng, Xiaoyan, Wen, Kenneth, Zhong, Mike, Zhang, Li, Munshi, Nikhil C., Qiu, Lugui, Tai, Yu-Tzu, Anderson, Kenneth C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2016
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034739/
https://ncbi.nlm.nih.gov/pubmed/27418644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707547
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