Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms remain elusive as to whether myeloma-supporting OCs also induce suppressive immune bone marrow (BM) microenvironment. Here, we f...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: An, Gang, Acharya, Chirag, Feng, Xiaoyan, Wen, Kenneth, Zhong, Mike, Zhang, Li, Munshi, Nikhil C., Qiu, Lugui, Tai, Yu-Tzu, Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034739/
https://ncbi.nlm.nih.gov/pubmed/27418644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707547
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