Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms remain elusive as to whether myeloma-supporting OCs also induce suppressive immune bone marrow (BM) microenvironment. Here, we f...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: An, Gang, Acharya, Chirag, Feng, Xiaoyan, Wen, Kenneth, Zhong, Mike, Zhang, Li, Munshi, Nikhil C., Qiu, Lugui, Tai, Yu-Tzu, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034739/
https://ncbi.nlm.nih.gov/pubmed/27418644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707547
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