Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms remain elusive as to whether myeloma-supporting OCs also induce suppressive immune bone marrow (BM) microenvironment. Here, we f...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: An, Gang, Acharya, Chirag, Feng, Xiaoyan, Wen, Kenneth, Zhong, Mike, Zhang, Li, Munshi, Nikhil C., Qiu, Lugui, Tai, Yu-Tzu, Anderson, Kenneth C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2016
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034739/
https://ncbi.nlm.nih.gov/pubmed/27418644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707547
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