Cysteine Palmitoylation of the γ Subunit Has a Dominant Role in Modulating Activity of the Epithelial Sodium Channel

The epithelial sodium channel (ENaC) is composed of three homologous subunits (α, β, and γ) with cytoplasmic N and C termini. Our previous work revealed that two cytoplasmic Cys residues in the β subunit, βCys-43 and βCys-557, are Cys-palmitoylated. ENaCs with mutant βC43A/C557A exhibit normal surfa...

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Main Authors: Mukherjee, Anindit, Mueller, Gunhild M., Kinlough, Carol L., Sheng, Nan, Wang, Zhijian, Mustafa, S. Atif, Kashlan, Ossama B., Kleyman, Thomas R., Hughey, Rebecca P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022901/
https://ncbi.nlm.nih.gov/pubmed/24692558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526020
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