Mycobacterium tuberculosis Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2

Mycobacterium tuberculosis (Mtb) employs multiple strategies to evade host immune responses and persist within macrophages. We have previously shown that the cell envelope-associated Mtb serine hydrolase, Hip1, prevents robust macrophage activation and dampens host pro-inflammatory responses, allowi...

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Hauptverfasser: Naffin-Olivos, Jacqueline L., Georgieva, Maria, Goldfarb, Nathan, Madan-Lala, Ranjna, Dong, Lauren, Bizzell, Erica, Valinetz, Ethan, Brandt, Gabriel S., Yu, Sarah, Shabashvili, Daniil E., Ringe, Dagmar, Dunn, Ben M., Petsko, Gregory A., Rengarajan, Jyothi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022732/
https://ncbi.nlm.nih.gov/pubmed/24830429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004132
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