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Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T cell immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th(1)) and IL-17 (Th(17)) are important for protecting against tuberculosis (TB), but the mec...
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| Udgivet i: | PLoS Pathog |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5540402/ https://ncbi.nlm.nih.gov/pubmed/28767735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006530 |
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