Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T cell immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th(1)) and IL-17 (Th(17)) are important for protecting against tuberculosis (TB), but the mec...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Sia, Jonathan Kevin, Bizzell, Erica, Madan-Lala, Ranjna, Rengarajan, Jyothi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540402/
https://ncbi.nlm.nih.gov/pubmed/28767735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006530
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