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GroEL stimulates protein folding through forced unfolding

Many proteins cannot fold without the assistance of chaperonin machines like GroEL and GroES. The nature of this assistance, however, remains poorly understood. Here we demonstrate that unfolding of a substrate protein by GroEL enhances protein folding. We first show that capture of a protein on the...

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Hlavní autoři: Lin, Zong, Madan, Damian, Rye, Hays S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744391/
https://ncbi.nlm.nih.gov/pubmed/18311152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1394
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