Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors

A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC(50) = 0.5...

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Bibliographic Details
Main Authors: Burmistrov, Vladimir, Morisseau, Christophe, Lee, Kin Sing Stephen, Shihadih, Diyala S., Harris, Todd R., Butov, Gennady M., Hammock, Bruce D.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019751/
https://ncbi.nlm.nih.gov/pubmed/24685540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.03.016
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