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Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC(50) = 0.5...
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| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019751/ https://ncbi.nlm.nih.gov/pubmed/24685540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.03.016 |
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