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Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC(50) = 0.5...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019751/ https://ncbi.nlm.nih.gov/pubmed/24685540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.03.016 |
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