Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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Autores principales: Cheng, Chiu-Min, Tzou, Shey-Cherng, Zhuang, Ya-Han, Huang, Chien-Chiao, Kao, Chien-Han, Liao, Kuang-Wen, Cheng, Ta-Chun, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Tai, Ming-Hong, Cheng, Tian-Lu
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019604/
https://ncbi.nlm.nih.gov/pubmed/24824752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097367
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