Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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מידע ביבליוגרפי
Main Authors: Cheng, Chiu-Min, Tzou, Shey-Cherng, Zhuang, Ya-Han, Huang, Chien-Chiao, Kao, Chien-Han, Liao, Kuang-Wen, Cheng, Ta-Chun, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Tai, Ming-Hong, Cheng, Tian-Lu
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019604/
https://ncbi.nlm.nih.gov/pubmed/24824752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097367
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