Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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Bibliografische gegevens
Hoofdauteurs: Cheng, Chiu-Min, Tzou, Shey-Cherng, Zhuang, Ya-Han, Huang, Chien-Chiao, Kao, Chien-Han, Liao, Kuang-Wen, Cheng, Ta-Chun, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Tai, Ming-Hong, Cheng, Tian-Lu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019604/
https://ncbi.nlm.nih.gov/pubmed/24824752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097367
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