Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System

Single-chain variable fragments (scFvs) serve as an alternative to full-length monoclonal antibodies used in research and therapeutic and diagnostic applications. However, when recombinant scFvs are overexpressed in bacteria, they often form inclusion bodies and exhibit loss of function. To overcome...

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Detalhes bibliográficos
Main Authors: Cheng, Chiu-Min, Tzou, Shey-Cherng, Zhuang, Ya-Han, Huang, Chien-Chiao, Kao, Chien-Han, Liao, Kuang-Wen, Cheng, Ta-Chun, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Tai, Ming-Hong, Cheng, Tian-Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019604/
https://ncbi.nlm.nih.gov/pubmed/24824752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097367
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