Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

Systemic injection of therapeutic antibodies may cause serious adverse effects due to on-target toxicity to the antigens expressed in normal tissues. To improve the targeting selectivity to the region of disease sites, we developed protease-activated pro-antibodies by masking the binding sites of an...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Chen, I-Ju, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Lu, Yun-Chi, Lin, Wen-Wei, Huang, Chien-Chiao, Cheng, Ta-Chun, Cheng, Yi-An, Cheng, Kai-Wen, Wang, Yeng-Tseng, Chen, Fang-Ming, Cheng, Tian-Lu, Tzou, Shey-Cherng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599682/
https://ncbi.nlm.nih.gov/pubmed/28912497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11886-7
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