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An ATP-competitive inhibitor modulates the allosteric function of the HER3 pseudokinase
The human epidermal growth factor receptor 3 (HER3) is a receptor tyrosine kinase that lacks catalytic activity, but is essential for cellular homeostasis due to its ability to allosterically activate EGFR/HER2. Though catalytically inactive, HER3 binds ATP tightly, hinting at a possible role of the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018233/ https://ncbi.nlm.nih.gov/pubmed/24656791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.02.011 |
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