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Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations
The human epidermal growth factor receptor (HER) tyrosine kinases homo- and hetero-dimerize to activate downstream signaling pathways. HER3 is a catalytically impaired member of the HER family that contributes to the development of several human malignancies and is mutated in a subset of cancers. HE...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492339/ https://ncbi.nlm.nih.gov/pubmed/25468994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005786 |
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