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Inhibitors in AKTion: ATP-competitive vs allosteric
Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly classified as either ATP-competitive or allosteric, are cu...
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| Publicado no: | Biochem Soc Trans |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7329346/ https://ncbi.nlm.nih.gov/pubmed/32453400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190777 |
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