Yüklüyor......
An ATP-competitive inhibitor modulates the allosteric function of the HER3 pseudokinase
The human epidermal growth factor receptor 3 (HER3) is a receptor tyrosine kinase that lacks catalytic activity, but is essential for cellular homeostasis due to its ability to allosterically activate EGFR/HER2. Though catalytically inactive, HER3 binds ATP tightly, hinting at a possible role of the...
Kaydedildi:
| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018233/ https://ncbi.nlm.nih.gov/pubmed/24656791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.02.011 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|