Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors

[Image: see text] Bacterial RNA polymerase (RNAP) is essential for transcription and is an antibacterial target for small molecule inhibitors. The binding region of myxopyronin B (MyxB), a bacterial RNAP inhibitor, offers the possibility of new inhibitor design. The molecular design program SPROUT h...

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Bibliografische gegevens
Hoofdauteurs: McPhillie, Martin J., Trowbridge, Rachel, Mariner, Katherine R., O’Neill, Alex J., Johnson, A. Peter, Chopra, Ian, Fishwick, Colin W. G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2011
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017976/
https://ncbi.nlm.nih.gov/pubmed/24900260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200087m
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