Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular anchors for the recruitment of epigenetic corepressors of the multifaceted DRED complex, thereby leading to ε- and γ-globin transcriptional repr...

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Hlavní autoři: Shi, Lihong, Sierant, M. C., Gurdziel, Katherine, Zhu, Fan, Cui, Shuaiying, Kolodziej, Katarzyna E., Strouboulis, John, Guan, Yuanfang, Tanabe, Osamu, Lim, Kim-Chew, Engel, James Douglas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014424/
https://ncbi.nlm.nih.gov/pubmed/24811540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004339
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