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Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes

The orphan nuclear receptors TR2 and TR4 have been shown to play key roles in repressing the embryonic and fetal globin genes in erythroid cells. However, combined germline inactivation of Tr2 and Tr4 leads to periimplantation lethal demise in inbred mice. Hence, we have previously been unable to ex...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Cui, Shuaiying, Tanabe, Osamu, Sierant, Michael, Shi, Lihong, Campbell, Andrew, Lim, Kim-Chew, Engel, James Douglas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342359/
https://ncbi.nlm.nih.gov/pubmed/25561507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-605022
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