Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular anchors for the recruitment of epigenetic corepressors of the multifaceted DRED complex, thereby leading to ε- and γ-globin transcriptional repr...

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Autores principales: Shi, Lihong, Sierant, M. C., Gurdziel, Katherine, Zhu, Fan, Cui, Shuaiying, Kolodziej, Katarzyna E., Strouboulis, John, Guan, Yuanfang, Tanabe, Osamu, Lim, Kim-Chew, Engel, James Douglas
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014424/
https://ncbi.nlm.nih.gov/pubmed/24811540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004339
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