Improved Normalization of Systematic Biases Affecting Ion Current Measurements in Label-free Proteomics Data

Normalization is an important step in the analysis of quantitative proteomics data. If this step is ignored, systematic biases can lead to incorrect assumptions about regulation. Most statistical procedures for normalizing proteomics data have been borrowed from genomics where their development has...

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Bibliographic Details
Main Authors: Rudnick, Paul A., Wang, Xia, Yan, Xinjian, Sedransk, Nell, Stein, Stephen E.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2014
Subjects:
Technological Innovation and Resources
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014289/
https://ncbi.nlm.nih.gov/pubmed/24563535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.030593
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