c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

Increasing evidence suggests that the c-Abl protein tyrosine kinase could play a role in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. c-Abl has been shown to regulate the degradation of two proteins implicated in the pathogenesis of PD, parkin and α-synucl...

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Auteurs principaux: Mahul-Mellier, Anne-Laure, Fauvet, Bruno, Gysbers, Amanda, Dikiy, Igor, Oueslati, Abid, Georgeon, Sandrine, Lamontanara, Allan J., Bisquertt, Alejandro, Eliezer, David, Masliah, Eliezer, Halliday, Glenda, Hantschel, Oliver, Lashuel, Hilal A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014189/
https://ncbi.nlm.nih.gov/pubmed/24412932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt674
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