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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease (PD). Therefore, lowering α-synuclein levels represents a viable therapeutic strategy for the treatment of PD and related syn...

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書目詳細資料
Main Authors: Oueslati, Abid, Schneider, Bernard L., Aebischer, Patrick, Lashuel, Hilal A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799334/
https://ncbi.nlm.nih.gov/pubmed/23983262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309991110
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