Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Fares, Mohamed-Bilal, Maco, Bohumil, Oueslati, Abid, Rockenstein, Edward, Ninkina, Natalia, Buchman, Vladimir L., Masliah, Eliezer, Lashuel, Hilal A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763739/
https://ncbi.nlm.nih.gov/pubmed/26839406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512876113
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