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Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease
Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4763739/ https://ncbi.nlm.nih.gov/pubmed/26839406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512876113 |
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