Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo

Although α-synuclein (α-syn) phosphorylation has been considered as a hallmark of sporadic and familial Parkinson disease (PD), little is known about the effect of PD-linked mutations on α-syn phosphorylation. In this study, we investigated the effects of the A30P, E46K, and A53T PD-linked mutations...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mbefo, Martial Kamdem, Fares, Mohamed-Bilal, Paleologou, Katerina, Oueslati, Abid, Yin, Guowei, Tenreiro, Sandra, Pinto, Madalena, Outeiro, Tiago, Zweckstetter, Markus, Masliah, Eliezer, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392248/
https://ncbi.nlm.nih.gov/pubmed/25657004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610774
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