Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

Phosphorylation of α-synuclein (α-syn) at Ser-129 is a hallmark of Parkinson disease and related synucleinopathies. However, the identity of the natural kinases and phosphatases responsible for regulating α-syn phosphorylation remain unknown. Here we demonstrate that three closely related members of...

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Auteurs principaux: Mbefo, Martial K., Paleologou, Katerina E., Boucharaba, Ahmed, Oueslati, Abid, Schell, Heinrich, Fournier, Margot, Olschewski, Diana, Yin, Guowei, Zweckstetter, Markus, Masliah, Eliezer, Kahle, Philipp J., Hirling, Harald, Lashuel, Hilal A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Protein Synthesis, Post-Translational Modification, and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807335/
https://ncbi.nlm.nih.gov/pubmed/19889641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081950
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