Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

Phosphorylation of α-synuclein (α-syn) at Ser-129 is a hallmark of Parkinson disease and related synucleinopathies. However, the identity of the natural kinases and phosphatases responsible for regulating α-syn phosphorylation remain unknown. Here we demonstrate that three closely related members of...

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Detaylı Bibliyografya
Asıl Yazarlar: Mbefo, Martial K., Paleologou, Katerina E., Boucharaba, Ahmed, Oueslati, Abid, Schell, Heinrich, Fournier, Margot, Olschewski, Diana, Yin, Guowei, Zweckstetter, Markus, Masliah, Eliezer, Kahle, Philipp J., Hirling, Harald, Lashuel, Hilal A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807335/
https://ncbi.nlm.nih.gov/pubmed/19889641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081950
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