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Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance

The effects of ABL1/ABL inhibition on clearance of SNCA/α-synuclein were evaluated in animal models of α-synucleinopathies. Parkinson disease (PD) is a movement disorder characterized by death of dopaminergic substantia nigra (SN) neurons and brain accumulation of SNCA. The tyrosine kinase ABL1 is a...

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Autors principals: Hebron, Michaeline L., Lonskaya, Irina, Moussa, Charbel E.-H.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748197/
https://ncbi.nlm.nih.gov/pubmed/23787811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.25368
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