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Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2013
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944464/ https://ncbi.nlm.nih.gov/pubmed/23737459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302771 |
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