Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

Parkinson’s disease (PD) is a movement disorder associated with genetic and age related causes. Although autosomal recessive early onset PD linked to parkin mutations does not exhibit α-Synuclein accumulation, while autosomal dominant and sporadic PD manifest with α-Synuclein inclusions, loss of dop...

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Autores principales: Lonskaya, Irina, Desforges, Nicole M., Hebron, Michaeline L., Moussa, Charbel E-H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873413/
https://ncbi.nlm.nih.gov/pubmed/24386307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083914
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