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Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance
Parkinson’s disease (PD) is a movement disorder associated with genetic and age related causes. Although autosomal recessive early onset PD linked to parkin mutations does not exhibit α-Synuclein accumulation, while autosomal dominant and sporadic PD manifest with α-Synuclein inclusions, loss of dop...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873413/ https://ncbi.nlm.nih.gov/pubmed/24386307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083914 |
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