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Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with amyloid accumulation and autophagic changes. Parkin is an E3 ubiquitin ligase involved in proteasomal and autophagic clearance. We previously demonstrated decreased parkin solubility and interaction with the key autophagy enzym...

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書誌詳細
主要な著者: Lonskaya, Irina, Hebron, Michaeline L., Desforges, Nicole M., Schachter, Joel B., Moussa, Charbel E-H
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975659/
https://ncbi.nlm.nih.gov/pubmed/24337465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1112-3
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