Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin...

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Hlavní autoři: Lonskaya, Irina, Hebron, Michaeline L, Desforges, Nicole M, Franjie, Alexander, Moussa, Charbel E-H
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944464/
https://ncbi.nlm.nih.gov/pubmed/23737459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302771
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