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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease (PD). Therefore, lowering α-synuclein levels represents a viable therapeutic strategy for the treatment of PD and related syn...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799334/ https://ncbi.nlm.nih.gov/pubmed/23983262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309991110 |
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