The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity

Over the last two decades, the identification of missense mutations in the α-synuclein (α-Syn) gene SNCA in families with inherited Parkinson disease (PD) has reinforced the central role of α-Syn in PD pathogenesis. Recently, a new missense mutation (H50Q) in α-Syn was described in patients with a f...

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Detalhes bibliográficos
Main Authors: Khalaf, Ossama, Fauvet, Bruno, Oueslati, Abid, Dikiy, Igor, Mahul-Mellier, Anne-Laure, Ruggeri, Francesco Simone, Mbefo, Martial K., Vercruysse, Filip, Dietler, Giovanni, Lee, Seung-Jae, Eliezer, David, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139205/
https://ncbi.nlm.nih.gov/pubmed/24936070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.553297
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