Semisynthetic and in vitro phosphorylation of alpha-synuclein at Y39 promotes functional partly-helical membrane-bound states resembling those induced by PD mutations

Alpha-synuclein is a presynaptic protein of poorly understood function that is linked to both genetic and sporadic forms of Parkinson’s disease. We have proposed that alpha-synuclein may function specifically at synaptic vesicles docked at the plasma membrane, and that the broken-helix state of the...

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Published in:ACS Chem Biol
Main Authors: Dikiy, Igor, Fauvet, Bruno, Jovičić, Ana, Mahul-Mellier, Anne-Laure, Desobry, Carole, El-Turk, Farah, Gitler, Aaron D., Lashuel, Hilal A., Eliezer, David
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240779/
https://ncbi.nlm.nih.gov/pubmed/27356045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00539
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